Study design
We conducted a two-stage study. The first study followed a randomised placebo-controlled trial (RCT) to identify factors that may be associated with weight-related adverse events in overweight and obese people.
Treatment
The second study followed a randomised placebo-controlled trial (RCT) to identify factors that may be associated with obesity and/or overweight in people with type 2 diabetes or overweight.
Outcomes
The primary outcome is a composite measure of cardiovascular events, diabetes, dyslipidaemia, heart failure, or other adverse events. Secondary outcomes are weight loss, insulin resistance, blood pressure, and other measures of lipid profiles. A score of ≥3 points indicates a composite measure of cardiovascular events, diabetes, dyslipidaemia, heart failure, or other events.
We will include participants with ≥1 event per month and ≥1 weight loss per month for the RCT and the placebo-controlled trial. We will include participants with ≥1 event per month for the RCT and the placebo-controlled trial.
Participants
Participants will be recruited from the online recruitment site and will have a BMI >30 kg/m2 (mean age 49 years).
Methods
The study is designed to recruit participants from 1 July 2018. The study is a double-blind RCT. The participants will be randomised to receive either diet pills or placebo (both containing orlistat) for 12 weeks in a randomised, double-blind fashion. Participants will then be randomised to a combination of diet pills (either diethline, the combination of diethline and placebo), exercise pills (either diethline, the combination of diethline and placebo), or placebo. The study is not designed to involve weight-loss trials. Participants will not have access to a study card.
Participants will be screened and enrolled at each visit. Participants will be randomised to receive either diet pills (either diethline or diethline plus placebo) or placebo for 12 weeks in a randomised fashion. Participants will then be randomised to either diet pills (either diethline or diethline plus placebo) or placebo. Participants will be randomised to either diet pills (either diethline or diethline plus placebo) or placebo.
Participants will be given a baseline assessment, followed by a 2-week follow-up. Participants will be randomised to either diet pills or placebo for 12 weeks in a randomised fashion. Participants will be given a follow-up assessment at the end of the 12-week period. Participants will be given a trial-specific questionnaire to assess weight loss over the 12-week period.
Participants will be assessed and randomised to either diet pills or placebo for a 2-week follow-up. Participants will be given a random number to be randomised to either diet pills or placebo. Participants will be given a study-specific questionnaire to assess weight loss over the 12-week period.
Orlistat is used to treat obesity and help in weight loss. Orlistat is to be used along with a low-calorie diet and regular physical exercise. Obesity is a common condition associated with excessive body fat, which in turn increases the risk of other health problems such as diabetes, high blood pressure, certain cancers, and heart disease. Intake of more calories than you burn by exercise or daily activities results in obesity.
Orlistat contains Orlistat, which works in the small intestine and stomach and prevents the action of enzymes that break down fat, which is absorbed by the body. Orlistat decreases the absorption of fat from the food you eat. Thus, fat passes through the gut and is excreted in the faeces, which makes the body unable to use fat as a source of energy or convert it into fat tissue. Thereby, Orlistat helps in weight loss.
Take Orlistat as prescribed by your doctor. You are advised to take Orlistat for as long as your doctor has prescribed it for you based on your medical condition. Some people may experience soft stools, sudden bowel motions, flatulence (gas) with or without oily spotting, oily or fatty stools, stomach pain, stool incontinence (involuntary leakage of stools), and runny or liquid stools. Most of these side effects of Orlistat do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.
If you are allergic to Orlistat or any other medicines, please tell your doctor. Avoid taking Orlistat if you are pregnant or planning for pregnancy, as it may cause fetal harm. It is not known whether Orlistat is excreted in human milk. Therefore, please consult a doctor if you are a breastfeeding woman. Orlistat is not recommended for children below 18 years of age, as the safety and effectiveness were not established. You are advised to take a multivitamin containing fat-soluble vitamins such as A, D, E, and K at bedtime as Orlistat may reduce the absorption of certain vitamins in the body.
ContraindicationsThe following drugs are contraindicated when taking Orlistat:
Tell your doctor about all your current medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially,Anticoagulants, Antidepressants, Calcium Channel Blockers, Diltiazem, Crizotinib, Flibanserin, Quinolones, lithium, lithium, phenylbutazone, phenobarbital, tricyclic antidepressants, tricyclic antidepressants, tricyclic antidepressants, citalopram, diltiazem, hydroxyzine, methyladihydroergerganserine, and midazolam.Pregnancy and breastfeeding : Do not take Orlistat if you are pregnant or breastfeeding without consulting a doctor. If you are pregnant or breastfeeding, inform your doctor before taking Orlistat. Also, if you are breastfeeding, tell your doctor before taking Orlistat. Because of the possibility of experiencing allergic reactions, avoid taking Orlistat if you are allergic to Orlistat. Also, inform your doctor if you are taking other medicines such as warfarin (Lumavik), phenytoin (Dilantin), cyclophosphamide (inoculation in chemotherapy), metformin (inoculation in chemotherapy), vincristine (inoculation in chemotherapy), etoposide (inoculation in immune-compromising situations), and fusidic acid (inoculation in chemotherapy).
positivityOrlistat may cause sensitivity in the body.
Salt Composition in both
Salt Composition
Orlistat 120mg(same for both)
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The recommended starting dose is 120mg which can be increased to the 120mg dosage in STORACH 120 mg (120mg is the recommended starting dose). Take this at least one hour prior to eating, changing the amount of food you eat and staying in your stomach can help reduce potential stomach upset.
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The obesity pill Xenical is a weight loss medication. It’s a weight loss pill that’s used to help people lose weight. The drug works by blocking the absorption of fat from the intestines. This results in less fat being passed out of the body. The drug is taken once or twice per day. Orlistat, orlistat, is a drug that is used to help people lose weight. It’s a weight loss pill that’s taken once a day in a pill. Orlistat is taken by mouth. The drug is taken by mouth.
Orlistat is a medication that is taken by mouth to help people who have a stomach ulcer. The drug is a prescription drug. It has the same active ingredient as Xenical. The drug is taken by mouth every day. The drug has no side effects. If you take orlistat before bed, it can take some time to work and is not effective. However, it’s important to use it consistently.
Orlistat comes as a pill and an oral tablet. It is taken once a day. It is usually taken with food. The dosage is based on weight loss, how the body reacts to the medication, and other factors. The drug works in the body to reduce the amount of fat in the intestines. The drug is taken by mouth once or twice per day. The drug has the same active ingredient as Xenical. The dosage is based on weight loss, how the body responds to the medication, and other factors.
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